GPC, also known as Size Exclusion Chromatography (SEC), is the most direct method for determining the molecular weight distribution of a sample.  This technique is fundamental in analytical testing as the molecular weight of a material is directly related to its physical properties and industrial grade.  During Standardized GPC, sample components are dissolved in a suitable solvent, chromatographically separated based on molecular size, detected using a Refractive Index detector and compared to standards of known molecular weight.  The most important aspect of a successful GPC analysis is the achievement of a purely size-based separation.  The correct mobile phase and column stationary phase must be chosen to decrease the potential for column-sample interaction and retention.  RQM+'s 100% divinylbenzene (DVB) resin is functionalized to reduce the aforementioned chemical interactions through mechanisms such as charge-charge repulsion.  Thirty years ago, RQM+ was founded on the characterization technique of GPC and we have continued to expand our capabilities ever since.  RQM+ now offers GPC analysis in practically all solvents at room temperature due to our extremely rugged and long-lasting DVB columns.

Trust your GPC analysis to the industry's most dependable and experienced GPC laboratory!

  • Determination of Mn, Mw, Mz and PDI
  • Degradation/Failure Analysis
  • Quality Control Analysis
  • Regulatory Polymer Exemption (determination of Weight Fraction below 500 and 1000 Daltons)
  • Development of a material-specific method followed by formal validation
  • Quantitation of Polymeric and Oligomeric components

RQM+'s team of PhD chemists have written several white papers on GPC found below.


Related standards

  • Environmental Protection Agency

We are passionate about your success. Tell us more about your regulatory and quality needs to learn about how we can help.

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